Advances in hydrotropic solutions: an updated review

Physical materials technology

Approximately a century ago, in 1916, the term ‘hydrotropy’ was coined by the scientist Carl A. Neuberg to address anionic organic salts which considerably augmented the aqueous solubility of poorly soluble solutes. Currently hydrotropic solutions possess high industrial demand due to their unique features, such as easy availability, good recovery, absence of fire hazards, high separation factors without any solutes emulsification problem and eco-friendly nature. The present review takes the readers through a concise overview, geometrical features of hydrotropic agents, hypothetical mechanisms and their different advances towards drug delivery. Moreover, this review would provide an insight into the future perspectives concerned with drug delivery and hydrotropism.