A spatial structure model of the complex formed by methionine-sulfoxide reductase B1 and thioredoxin in mouse redox system

St. Petersburg Polytechnic University Journal - Physics and Mathematics Peter the Great St. Petersburg Polytechnic University

Since 2008

ISSN 2304-9782

ISSN 2618-8686

ISSN 2405-7223

Year: 2010 Issue: 3 (104)

Pages: 190

10 163846

Previous issue All issues Next issue

5701

0

UDK: 577.325.2, 004.942

Article type: Research Article

Latest issues

A spatial structure model of the complex formed by methionine-sulfoxide reductase B1 and thioredoxin in mouse redox system

Biophysics and medical physics

Authors:

Rychkov Georgy N. Zolotukhin Kirill O. Nerinovskii Kirill B. Dikiy Alexander I.

Abstract:

On the basis of data obtained by protein docking and refined by molecular dynamics technique, we have built a spatial model of complex formed by MsrBl and Trx mouse proteins. Protein interaction is facilitated by formation of intermolecular P-sheet, that results in disulfide bond stretching in oxidized state of MsrBl.