Porous structure forming of the aliphatic copolyamide films

Biophysics and medical physics

The effects of concentration and viscosity of the copolyamide (CoPA) (copolymer of ε-caprolactam and hexamethylendiaminadipate) solutions in aqueous/alcoholic solvents on their phase state have been studied. To study the CoPA solution phase state the light scattering method was used. The start of the phase separation was estimated by the determination of the turbidity point. The films obtained by the coagulation method were characterized by monodisperse pores distribution with an average pore size of 1.3 µm. Mechanical properties, water permeability of the porous films and the specific surface areas according to BET method were measured. Using scanning electron microscopy it was found that proliferation of mesenchymal ASCs stem cells on such porous films were characterized by good adhesion of cells to CoPA matrix. It was shown that the porous structure, transport and mechanical properties of those CoPA films allowed their application as two-dimensional matrices for cellular technology.