Laser blood vessel reconstruction is a modern, non-invasive method of blood vessel closure. Until now, most previous work has used protein and dye-based solders (laser absorbers) to form welds. However, the addition of  nanoparticles to the solder, which have outstanding bactericidal properties and the ability to accelerate wound epithelialisation, has the potential to improve the efficiency of optical wound healing. The aim of the study was to experimentally investigate the physicochemical properties of dispersed solders including antibacterial nanoparticles of metals Ni, Al, Fe3O4 and carbon nanotubes with metallic properties, biopolymer – albumin, and dye localizing  laser radiation in the area of wound dissection – indocyanine green, the formation of a biological tissue compound and the study of their mechanical properties. The selected nanoparticles have a high absorption coefficient of laser  radiation, which provides high efficiency of laser energy utilization and allows recovery with minimal losses. The effectiveness of solders with different metal nanoparticles was experimentally tested in cattle vessels. Tissue  reconstruction was performed by diode laser with a wavelength of 810 nm. The suture was formed within 1 minute. The laser exposure temperature was 55 °C for each particular specimen. The results showed that the highest tensile  strength was in the specimen with carbon nanotubes. The achieved strength with carbon nanotubes was 950 kPa.