Quantum dots (QDs) is a class of fluorescent label widely using for biological and biomedical applications. The unique optical properties of QDs make them promising tool as fluorescent markers and analytical labels of proteins. To apply them in biological fluids it is essential to coat QDs with biocompatible polymers. In this research CdTe/CdS/ZnS QDs with mercaptopropionic acid as stabilizer was coated with carboxymethyl chitosan (CMC) by electrostatic interactions. The physicochemical properties of resulting QDs-CMC were studied by absorption and fluorescence spectroscopy, dynamic light scattering and capillary zone electrophoresis.