Quantum key distribution (QKD) is a well-studied field of science and is becoming a common technology. Commercial systems become more available. Such systems require high level of automatization, so, the set of real-time and prior calibrations is required for them. In this work, we propose calibration algorithms that pre-tune the amplitude of pulses and the laser wavelength and also maintain phase and polarization of weak coherent pulses during generation. Described algorithms were implemented on a prototype of the commercial QKD system and demonstrated high results.