The necessity of using a single-molecule sequencer in biology and medicine is substantiated. The role of sample preparation in conducting these studies is noted. It was noted that with increasing requirements for the results of genetic studies, it is necessary to modernize and develop new designs of sample preparation units. The study performs the sample preparation unit, which can be applied for experiments with biological materials, particularly for genetic research. The main components of the system were introduced, such as position module, sample loader and temperature control module. Test trials of the water dozing and thermal stabilization were carried out.