The work is devoted to fabrication of the mechanical pressure sensors based on zinc oxide microwires (ZnO MWs) synthesized via low-temperature hydrothermal method. The ZnO MWs were encapsulated in Poly(dimethylsiloxane) (PDMS) membrane by G-coating technique between two ceramic substrates with interdigital gold contacts. The correlation between the mechanical load applied to the sensor and its electrophysical characteristics is studied with electrical impedance spectroscopy. The results of the work are of interest for the development of pressure sensors, in particular for miniature portable flexible health monitoring systems.