The radiation hardness of the operational amplifiers IS-OU2 and LM358 has been performed experimentally using X-ray research complex. It was found that the measured characteristics of operational amplifiers (input offset voltage, consumption current, voltage gain) for the IS-OU2 and its analogue LM358 are similar and demonstrate radiation hardness. As a result, the designed and produced IS-OU2 operational amplifier can be used for producing of spacecraft equipment electronics that can operate under space radiation conditions.