The work considers the possibility of creating microfluidic topology elements on a stainless-steel plate using laser processing. The results of multi-stage exposure of near IR laser radiation to a metal surface in order to create  microchannel parts (grooves) with a semicircular profile, as well as through holes that form part of typical microfluidic topologies, are presented. This paper describes the main technological features of the effect of laser radiation on  a metal plate, which affect the effectiveness of creating microtopology elements.