A new method of express diagnostics of the health state based on the results of non-invasive measurements of the pulse waveform, pulse values, blood pressure, and oxygen saturation of blood vessels and tissues is considered. The feature of these measurements is that they can be carried out both in the hospital and at home (a person can implement them independently). To measure tissue oxygen saturation, a new optical hardware-software complex has been developed, which is compact and portable. The results of experimental studies of various people are presented.