This study investigates multilayer structures of Al-CuO formed on the surfaces of sitall substrates using magnetron sputtering. The influence of changing the total thickness of the multilayer structure on the character and speed of the combustion front, characteristics of the reaction products, and gas emission levels is analyzed. Increasing the total thickness of the multilayer structure leads to changes in the speed and behavior of the combustion wave, as well as variations in the quantity, size, and form of the combustion products. The analysis includes theoretical data obtained using the Thermo software and experimental investigations. Gas emission values at different reaction temperatures have been evaluated.