This article presents methods for modifying the structures of an antiresonant optical fiber with a hollow cardiovascular system, with the help of which it is possible to detect a large number of active substances without resorting to the ways and technological processes of cardiovascular diseases. To obtain luminescence centers, a hollow antiresonant fiber is bound to capillaries with a solution of a YAG:Yb3+ composite and an organic solvent of dimethylformamide. After the procedure, several processing options are identified that cause the stocks of blanks to dry under normal conditions at a temperature of 150 °C and heat treatment at a temperature of 1000 °C. As a result, film tissues based on YAG:Yb3+ were formed inside the capillaries. The obtained luminescence peaks in the main and one of the additional peaks for YAG:Yb3+.