St. Petersburg Polytechnic University Journal: Physics and Mathematics Научно-технические ведомости СПбГПУ. Физико-математические науки 2304-9782, 2618-8686, 2405-7223 4 A spatial structure model of the complex formed by methionine-sulfoxide reductase B1 and thioredoxin in mouse redox system Модель пространственной структуры комплекса белков метионинсульфоксид-редуктазы B1 и тиоредоксин окислительно-восстановительной системы мыши Rychkov Georgy rychkov@omrb.pnpi.spb.ru Zolotukhin Kirill bi-bi_boy@mail.ru Nerinovskii Kirill Dikiy Alexander alex.dikiy@biotech.ntnu.no Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre «Kurchatov Institute» Peter the Great St. Petersburg Polytechnic University 18 10 2010 3 104 27 32

On the basis of data obtained by protein docking and refined by molecular dynamics technique, we have built a spatial model of complex formed by MsrBl and Trx mouse proteins. Protein interaction is facilitated by formation of intermolecular P-sheet, that results in disulfide bond stretching in oxidized state of MsrBl.

 cell redox system methionine-sulfoxide reductase tioredoxin protein complex mechanism of interaction